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占成，北京生命科學(xué)研究所 影像中心主任， 副研究員

Email: zhancheng@nibs.ac.cn

電話： 010-80726688-8870

傳真： 010-80724500

Room Number： B058

教育背景

2011   博士，生物醫(yī)學(xué)工程，華中科技大學(xué)

2006   碩士，生物醫(yī)學(xué)工程，華中科技大學(xué)

工作經(jīng)歷

2011-至今    影像中心主任，副研究員，北京生命科學(xué)研究所

2006-2008 工程師，北京生命科學(xué)研究所

研究概述

NIBS影像中心為研究所各實(shí)驗(yàn)室提供生物光學(xué)成像服務(wù)，中心現(xiàn)有多套高級光學(xué)顯微成像系統(tǒng)，包括激光點(diǎn)掃描共聚焦顯微鏡，轉(zhuǎn)盤式共聚焦顯微鏡，雙光子顯微鏡，以及玻片掃描顯微鏡，可以對固定切片、培養(yǎng)細(xì)胞和活體動植物細(xì)胞等多種生物樣品進(jìn)行光學(xué)成像實(shí)驗(yàn)。在提供服務(wù)的同時，影像中心也致力于開發(fā)一些新的光學(xué)成像技術(shù)和方法，解決一些具體的實(shí)驗(yàn)技術(shù)難題，取得了一系列成果（PNAS 2018, Dev Cell 2018, Oncotarget 2015, Nature 2014）。

另一方面，我們還獨(dú)立開展神經(jīng)生物學(xué)方面的研究，尤其對大腦如何調(diào)控機(jī)體的能量代謝感興趣。大腦通過自主神經(jīng)系統(tǒng)和神經(jīng)內(nèi)分泌系統(tǒng)調(diào)控機(jī)體各個器官的活動，實(shí)現(xiàn)對生理功能與行為的控制。過去和未來的幾年中，我們圍繞著大腦與外周器官如何相互作用實(shí)現(xiàn)代謝控制這一關(guān)鍵問題，從攝食調(diào)控（JNS 2013， Frontiers in neuroanatomy 2015）、血糖調(diào)控(Neuron 2018)，以及體溫調(diào)控等多個方面入手，運(yùn)用多種技術(shù)手段解析大腦調(diào)控代謝的神經(jīng)機(jī)制與物質(zhì)基礎(chǔ)。

發(fā)表文章

1、L. Mei, Y.Fan , M. Wang, X. Lv , C. Zhan#, E. Zhang#. Longitudinal in vivo recording of clock gene transcription in the brains of freely-moving mice. PNAS (2018). #co-corresponding author.

2、L. Mei , C. Zhan , E. Zhang. In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters. JOVE (2018).

3、Z. Zhao, L. Wang, W. Gao, F. Hu, J. Zhang, Y. Ren, R. Lin, Q. Feng, M. Cheng, D. Ju, Q. Chi, D. Wang, S. Song, M. Luo and C. Zhan# (2017). A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress. Neuron 95, 138-152 e135. Featured Article. # corresponding author.

4、D. Wang, X. He, Z. Zhao, Q.Feng, R.Lin, Y. Sun, T. Ding, F. Xu #, M. Luo #, C. Zhan # (2015) Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons. Frontiers in Neuroanatomy 9:40. # co-corresponding author.

5、C. Zhan*#, J. Zhou *, Q. Feng, J. Zhang, S. Lin, J. Bao, P. Wu, M. Luo #, Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively. J Neurosci 33:3624-3632, 2013. Selected for F1000Prime. # co-correspondence author, *co-fist author, co-corresponding author.
6、C. Zhan, M. Luo, Diverse patterns of odor representation by neurons in the anterior piriform cortex of awake mice. J Neurosci 30, 16662-16672, 2010.

7、S. Zeng, X. Lv, C. Zhan, W. R. Chen, et al. Simultaneous compensation for spatial and temporal dispersion of acousto-optical deflectors for two-dimensional scanning with a single prism. Optics Letters, 2006, 31(8): 1091-1093.

8、 Shen, E.Z., Song, C.Q., Lin, Y., Zhang, W.H., Su, P.F., Liu, W.Y., Zhang, P., Xu, J., Lin, N., Zhan, C., Wang, X., Shyr, Y., Cheng, H., and Dong, M.Q. Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans. Nature 508, 128-132.

9、Tang, Z., Hu, Y., Wang, Z., Jiang, K., Zhan, C., Marshall, W.F., and Tang, N. (2018). Mechanical Forces Program the Orientation of Cell Division during Airway Tube Morphogenesis. Dev Cell

10、Mengxiao Yu, Fuyou Li, Zhigang Chen, He Hu, C. Zhan, Hong Yang and Chunhui Huang, Laser Scanning Up-Conversion Luminescence Microscopy for Imaging Cells Labeled with Rare-Earth Nanophosphors, Anal. Chem. 2009, 81(3), 930–935.

11、H. Zhang, C. Zhan, J. Ke, Z. Xue, A. Zhang, K. Xu, Z. Shen, L. Yu, L. Chen, EGFR Kinase domain mutation positive lung cancers are sensitive to intrapleural perfusion with hyperthermic chemotherapy (IPHC) complete treatment, Oncotarget, DOI: 10.18632/oncotarget.6491. Dec. 8, 2015.

12、X. Lv, C. Zhan, S. Zeng, W. R. Chen, et al. Construction of multiphoton laser scanning microscope based on dual-axis acousto-optic deflector. Review of Scientific Instruments, 2006, 77(4).

13、Shaoqun Zeng, Xiaohua Lv, Kun Bi, C. Zhan, et al. Analysis of the dispersion compensation of acousto-optic deflectors used for multiphoton imaging. Journal of Biomedical Optics, 2007, 12(2).

書籍章節(jié)

Zhan C. POMC Neurons: Feeding, Energy Metabolism, and Beyond. In Neural Regulation of Metabolism. 2018 (pp. 17-29). Springer, Singapore.

國際專利

Shaoqun Zeng, Qingming Luo, C. Zhan, Xiaohua Lv. LIGHT PULSE POSITIONING WITH DISPERSION COMPENSATION. United States Patent, Patent No: US 7,821,698 B2, Published on Oct.26, 2010