曹鵬 博士
- 基本信息
- 教育經(jīng)歷
- 工作經(jīng)歷
- 研究概述
- 發(fā)表文章
曹鵬博士北京生命科學(xué)研究所高級(jí)研究員
Peng Cao, Ph.D. Associate Investigator, NIBS, Beijing, China
Phone: 86-10-80726688-8535
Fax: 86-10-80726689
E-mail: caopeng@nibs.ac.cn
教育經(jīng)歷
Education
2000年? 北京大學(xué)生命科學(xué)學(xué)院理學(xué)學(xué)士
B.Sc. Peking University, China
2005年 中國(guó)科學(xué)院生物物理研究所理學(xué)博士
Ph.D., Neurobiology, Institute of Biophysics, CAS
工作經(jīng)歷
Professional Experience
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2022-Present |
北京生命科學(xué)研究所?高級(jí)研究員 |
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Associate Investigator, National Institute of Biological Sciences, Beijing |
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2016-2022年 |
北京生命科學(xué)研究所 研究員 |
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Assistant Investigator, National Institute of Biological Sciences, Beijing |
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2012-2016年 |
中國(guó)科學(xué)院生物物理研究所 研究員 |
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Principle Investigator, Institute of Biophysics, CAS |
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2008-2012年 |
美國(guó)斯坦福大學(xué)醫(yī)學(xué)院/霍華德休斯醫(yī)學(xué)研究所 助理研究員 |
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Research Associate, HHMI at Stanford University |
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2005-2008年 |
美國(guó)貝勒醫(yī)學(xué)院分子生理及生物物理系 博士后 |
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Postdoctoral Associate, Baylor College of Medicine |
研究概述
在《物種起源》中，達(dá)爾文提出＂適者生存＂的重要概念。＂適者生存＂的關(guān)鍵是成功應(yīng)對(duì)生存威脅。微觀尺度上的生存威脅主要是病原微生物。它們可以入侵人和動(dòng)物的消化道和呼吸道，引發(fā)一系列病理性的防御反應(yīng)（如惡心和嘔吐）。宏觀尺度上的生存威脅主要是天敵。在面臨天敵威脅時(shí)，人和動(dòng)物表現(xiàn)出一系列生理性防御反應(yīng)（如戰(zhàn)斗和逃跑）。大腦如何感知這些不同尺度的生存威脅并啟動(dòng)相應(yīng)的防御反應(yīng)，是神經(jīng)科學(xué)領(lǐng)域一個(gè)重要的科學(xué)問(wèn)題。我們實(shí)驗(yàn)室以小鼠為動(dòng)物模型，在微觀尺度上，研究了大腦啟動(dòng)惡心和嘔吐的神經(jīng)機(jī)制；在宏觀尺度上，研究了大腦啟動(dòng)戰(zhàn)斗和逃跑的神經(jīng)機(jī)制。
研究?jī)?nèi)容-1: 大腦感知病原入侵啟動(dòng)防御反應(yīng)的神經(jīng)機(jī)制
食物中毒引發(fā)的惡心和嘔吐是機(jī)體自我保護(hù)的防御反應(yīng)，對(duì)生存具有重要的意義。惡心和嘔吐也是癌癥化療的主要副作用，具有重要的臨床意義。在過(guò)去三十年里，惡心和嘔吐的機(jī)制研究一直舉步維艱，因?yàn)轭I(lǐng)域內(nèi)缺乏合適的動(dòng)物模型和研究范式。
2022年11月1日，我們?cè)贑ell上發(fā)表了題為The gut-to-brain axis for toxin-induced defensive responses的研究論文。該研究建立了以小鼠為動(dòng)物模型研究惡心和嘔吐反應(yīng)的新范式，發(fā)現(xiàn)腸道報(bào)告病原入侵的“情報(bào)員”細(xì)胞，迷走神經(jīng)傳輸情報(bào)的“線人”細(xì)胞，以及腦內(nèi)負(fù)責(zé)啟動(dòng)惡心和嘔吐反應(yīng)的“開(kāi)關(guān)”細(xì)胞。在分子細(xì)胞層面上，揭示免疫反應(yīng)和5-羥色胺信號(hào)在引發(fā)惡心和嘔吐中的重要功能，證明化療藥物是通過(guò)“綁架”這些分子細(xì)胞機(jī)制引發(fā)惡心和嘔吐的副作用。研究還發(fā)現(xiàn)，這些分子細(xì)胞和神經(jīng)環(huán)路機(jī)制也參與了化療藥物（doxorubicin）引發(fā)的“惡心-嘔吐”副作用。這一發(fā)現(xiàn)暗示，化療藥物引發(fā)的“惡心-嘔吐”副作用，可能是通過(guò)綁架進(jìn)化上保守的“食物中毒”機(jī)制得以實(shí)現(xiàn)。
同期的 Cell 配發(fā)了專家評(píng)論文章，對(duì)這一工作進(jìn)行了詳細(xì)介紹。研究成果還被Nature Reviews Neuroscience以Research Highlight的形式進(jìn)行了報(bào)道。紐約時(shí)報(bào)也對(duì)這一研究成果進(jìn)行了采訪和報(bào)道。
研究?jī)?nèi)容-2:大腦感知天敵威脅啟動(dòng)“戰(zhàn)斗-逃跑”反應(yīng)的神經(jīng)機(jī)制
人和動(dòng)物在面臨生存威脅（例如天敵）時(shí),可以表現(xiàn)出“戰(zhàn)斗-逃跑”行為反應(yīng)，《水滸傳》中的武松打虎便是這一過(guò)程的生動(dòng)范例。在某些人群中，過(guò)度或反復(fù)的“戰(zhàn)斗-逃跑”行為反應(yīng)引發(fā)一類稱為創(chuàng)傷后壓力應(yīng)激障礙（PTSD）的精神疾病。要揭示一類疾病的發(fā)病機(jī)制，往往需要從源頭入手分析。解析引發(fā)“戰(zhàn)斗”和“逃跑”行為反應(yīng)的關(guān)鍵神經(jīng)環(huán)路可能是深入分析PTSD發(fā)病機(jī)理的突破口。近年來(lái),我們?cè)谶@一研究方向上取得一系列研究成果。
我們?cè)趯?shí)驗(yàn)室里建立了小鼠與天敵“戰(zhàn)斗”的行為范式，并發(fā)現(xiàn)天敵攻擊時(shí)產(chǎn)生的傷害性機(jī)械刺激是觸發(fā)小鼠戰(zhàn)斗行為的關(guān)鍵。我們?cè)谛∈蟮南虑鹉X前核 AHN中發(fā)現(xiàn)編碼傷害性機(jī)械刺激的神經(jīng)元。光激活這些神經(jīng)元，能直接引發(fā)小鼠對(duì)抗天敵的防御行為。抑制這些神經(jīng)元，小鼠失去了對(duì)抗天敵的能力。這一研究成果于2022年1月3日發(fā)表在Nature Neuroscience上。
大腦如何啟動(dòng)“逃跑”的行為反應(yīng)呢? 我們?cè)谛∈蟮拇竽X中發(fā)現(xiàn)一群?jiǎn)?dòng)逃避天敵行為的神經(jīng)元。這些神經(jīng)元位于一個(gè)叫做“上丘”的腦區(qū)，以小清蛋白（parvalbumin，PV）為生物標(biāo)記物。上丘PV神經(jīng)元可以像雷達(dá)一樣監(jiān)測(cè)天空中快速逼近的運(yùn)動(dòng)目標(biāo)，并把這些預(yù)警信息傳送給恐懼中樞杏仁核。直接刺激該神經(jīng)環(huán)路，可以快速引發(fā)強(qiáng)烈的逃跑行為。反復(fù)刺激該神經(jīng)環(huán)路，動(dòng)物出現(xiàn)類似PTSD的核心癥狀。這些科學(xué)發(fā)現(xiàn)于2015年6月26日發(fā)表在Science上。
以上關(guān)于“戰(zhàn)斗”和“逃跑”行為反應(yīng)的神經(jīng)機(jī)制的研究結(jié)果為進(jìn)一步深入研究PTSD的發(fā)病機(jī)理奠定了重要基礎(chǔ)。
Representative Publications
1. Zhiyong Xie, Xianying Zhang, Miao Zhao, Lifang Huo, Meizhu Huang, Dapeng Li, Shuangfeng Zhang, Xingyu Cheng, Huating Gu, Chen Zhang, Cheng Zhan, Fengchao Wang, Congping Shang, Peng Cao. The gut-to-brain axis for toxin-induced defensive responses. Cell 185: 4298-4316 (2022)
● Cell, “A gut-retching discovery”.
● Nature Reviews Neuroscience, “Gut-brain pathways for toxin defence”.
● The New York Times, “How brains send a signal that it’s time to vomit”.
2. Zhiyong Xie, Dapeng Li, Xinyu Cheng, Qing Pei, Meizhu Huang, Huating Gu, Miao Zhao, Dandan Geng, Fan Zhang, Yuanwu Ma, Peng Cao. A brain-to-spinal neural circuit for repetitive self-grooming in mice. Neuron 110: 874-890 (2022)
● Neuron, “Of pride and groom: The gains and limits of studying the neuroanatomy of rodent self-grooming in translational research”.
3. Zhiyong Xie, Huating Gu, Meizhu Huang, Xingyu Cheng, Yuan Xie, Zongxiang Tang, Fan Zhang, Peng Cao. Mechanically evoked defensive attack is controlled by GABAergic neurons in the anterior hypothalamic nucleus. Nature Neuroscience 25: 72-85 (2022)
4. Congping Shang, Aixue Liu, Dapeng Li, Zhiyong Xie, Zijun Chen, Meizhu Huang, Yang Li, Yi Wang, Wei Shen, Peng Cao. A subcortical excitatory circuit for sensory-triggered predatory hunting in mice. Nature Neuroscience 22: 909-920 (2019)
● Nature Neuroscience, “Hungry for motion: the senses propel predation”
5. Zhihui Liu, Zijun Chen, Congping Shang, Fei Yan, Yingchao Shi, Jiajing Zhang, Baole Qu, Hailin Han, Yanying Wang, Dapeng Li, Thomas Südhof, Peng Cao. IGF1-dependent synaptic plasticity of mitral cells in olfactory memory during social learning. Neuron 95: 106-122 (2017)
6. Congping Shang, Zhihui Liu, Zijun Chen, Yingchao Shi, Su Liu, Dapeng Li, Qian Wang, Peng Cao. A parvalbumin-positive excitatory visual pathway to trigger fear responses in mice. Science 348: 1472-77 (2015)
Other Publications
7. Ming-Ming Zhang, An-Qi Geng, Kun Chen, Jian Wang, Pan Wang, Xin-Tong Qiu, Jun-Xiang Gu, Hong-Wei Fan, Da-Yu Zhu, Shan-Ming Yang, Qi-Yu Chen, Zhao-Xiang Zhou, Bo-Yuan Fan, Yang Bai, Ke-Ke Xing, Jia-Ming Feng, Jun-Da Wang, Yan Chen, Ya-Cheng Lu, Ying Liang, Peng Cao, Bong-Kiun Kaang, Min Zhuo, Yun-Qing Li, Tao Chen. Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain. Neuron 110: 1993-2008.e6. (2022)
8. Jing-Jing Yan, Xiao-Jing Ding, Ting He, Ai-Xiao Chen, Wen Zhang, Zi-Xian Yu, Xin-Yu Cheng, Chuan-Yao Wei, Qiao-Dan Hu, Xiao-Yao Liu, Yan-Li Zhang, Mengge He, Zhi-Yong Xie, Xi Zha, Chun Xu, Peng Cao, Haohong Li, Xiao-Hong Xu. A circuit from the ventral subiculum to anterior hypothalamic nucleus GABAergic neurons essential for anxiety-like behavioral avoidance. Nature Communications 13 (1), 1-16 (2022)
9. Yuan Wang, Rong Huang, Zuying Chai, Changhe Wang, Xingyu Du, Yuqi Hang, Yongxin Xu, Jie Li, Xiaohan Jiang, Xi Wu, Zhongjun Qiao, Yinglin Li, Bing Liu, Xianying Zhang, Peng Cao, Feipeng Zhu, Zhuan Zhou Calcium-independent transmission at the central synapse formed between dorsal root ganglion and dorsal horn neurons. EMBO Reports 23 (11), e54507 (2022)
10. Meizhu Huang, Dapeng Li, Xinyu Cheng, Qing Pei, Zhiyong Xie, Huating Gu, Xuerong Zhang, Zijun Chen, Aixue Liu, Yi Wang, Fangmiao Sun, Yulong Li, Jiayi Zhang, Miao He, Yuan Xie, Fan Zhang, Xiangbin Qi, Congping Shang, Peng Cao. The tectonigral pathway regulates appetitive locomotion in predatory hunting in mice. Nature Communications 12: 4409 (2021)
11. Zhiyong Xie, Mengdi Wang, Zeyuan Liu, Congping Shang, Changjiang Zhang, Le Sun, Huating Gu, Gengxin Ran, Qing Pei, Qiang Ma, Meizhu Huang, Junjing Zhang, Rui Lin, Youtong Zhou, Jiyao Zhang, Miao Zhao, Minmin Luo, Qian Wu, Peng Cao, Xiaoqun Wang. Transcriptomic encoding of sensorimotor transformation in the midbrain. eLife 10: e69825 (2021)
12. Can Liu, Chia-Ying Lee, Greg Asher, Liqin Cao, Yuka Terakoshi, Peng Cao, Reiko Kobayakawa, Ko Kobayakawa, Katsuyasu Sakurai, Qinghua Liu. Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia. Nature Communications 12: 2648 (2021)
13. Chaojuan Yang, Yonglu Tian, Feng Su, Yangzhen Wang, Mengna Liu, Hongyi Wang, Yaxuan Cui, Peijiang Yuan, Xiangning Li, Anan Li, Hui Gong, Qingming Luo, Desheng Zhu, Peng Cao, Yunbo Liu, Xunli Wang, Min-hua Luo, Fuqiang Xu, Wei Xiong, Liecheng Wang, Xiang-yao Li, Chen Zhang. Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome. Protein & Cell (2021)
14. Shiwei Qiu, Weihao Zhao, Xue Gao, Dapeng Li, Weiqian Wang, Bo Gao, Weiju Han, Shiming Yang, Pu Dai, Peng Cao, Yongyi Yuan. Syndromic deafness gene ATP6V1B2 controls degeneration of spiral ganglion neurons through modulating proton flux. Frontiers in Cell and Developmental Biology 9: 742714 (2021).
15. Jing Chen, Mingxiu Cheng, Liang Wang, Lei Zhang, Dan Xu, Peng Cao, Fengchao Wang, Herbert Herzog, Sen Song, Cheng Zhan. A Vagal-NTS neural pathway that stimulates feeding. Current Biology 30: 3986-3998.e5. (2020)
16. Zheng-dong Zhao, Zongming Chen, Xinkuan Xiang, Mengna Hu, Hengchang Xie, Xiaoning Jia, Fang Cai, Yuting Cui, Zijun Chen, Lechen Qian, Jiashu Liu, Congping Shang, Yiqing Yang, Xinyan Ni, Wenzhi Sun, Ji Hu, Peng Cao, Haohong Li, Wei Shen. Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting. Nature Neuroscience 22: 921-932 (2019)
17. Congping Shang, Zijun Chen, Aixue Liu, Yang Li, Jiajing Zhang, Baole Qu, Fei Yan, Yaning Zhang, Weixiu Liu, Zhihui Liu, Xiaofei Guo, Dapeng Li, Yi Wang, Peng Cao. Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice. Nature Communications 9: 1232 (2018)
18. Yonglu Tian, Chaojuan Yang, Yaxuan Cui, Feng Su, Yongjie Wang, Yangzhen Wang, Peijiang Yuan, Shujiang Shang, Hao Li, Jizong Zhao, Desheng Zhu, Shiming Tang, Peng Cao, Yunbo Liu, Xunli Wang, Liecheng Wang, Wenbo Zeng, Haifei Jiang, Fei Zhao, Minhua Luo, Wei Xiong, Zilong Qiu, Xiang-Yao Li, Chen Zhang, An excitatory neural assembly encodes short-term memory in the prefrontal cortex. Cell Reports 22: 1734-1744 (2018)
19. Peng Cao, Xiaofei Yang, and Thomas Südhof, Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins. The Journal of Neuroscience 33: 1714-1727 (2013)
20. Xiaofei Yang, Peng Cao and Thomas Südhof. Deconstructing Complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes. PNAS 110: 20777-20782 (2013)
21. Peng Cao, Anton Maximov, and Thomas Südhof, Activity-dependent IGF1 exocytosis is controlled by the Ca2+-sensor synaptotagmin 10. Cell 145: 300–311 (2011).
● Cell, “An exciting calcium sensor for smell”.
● Nature Reviews Neuroscience, “Molecular neuroscience: Synaptotagmin 10-mediated release”.
22. Zhiping Pang, Wei Xu, Peng Cao and Thomas Südhof. Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons. Journal of Biological Chemistry 285: 33930-33939 (2010)
23. Zhiping Pang, Peng Cao, Wei Xu and Thomas Südhof. Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II. The Journal of Neuroscience 30: 4132-4142 (2010)
24. Yan Yang, Peng Cao, Yang Yang, and Shu-Rong Wang, Corollary discharge circuits for saccadic modulation of the pigeon visual system. Nature Neuroscience 11: 595-602 (2008)
25. Daoying Hu, Peng Cao, Edda Thiels, Charleen Chu, Gang-Yi Wu, Tim Oury, Eric Klann. Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. Neurobiology of Learning and Memory 87: 372-384 (2007)
26. Peng Cao, Yan Yang, Yang Yang and Shu-Rong Wang. Differential modulation of thalamic neurons by optokinetic nuclei in the pigeon. Brain Research 1069: 159-165 (2006)
27. Peng Cao, Yong Gu, and Shu-Rong Wang, Visual neurons in the pigeon brain encode the acceleration of stimulus motion. The Journal of Neuroscience 24: 7690–7698 (2004)
28. Quan Xiao, Peng Cao, Yong Gu and Shu-Rong Wang Visual responses of neurons in the pretectal nucleus lentiformis mesencephali to moving patterns within and beyond receptive fields in pigeons. Brain Behavior and Evolution 57: 80-86 (2001)
Reviews and Previews
29. Zhihui Liu, Peng Cao. Love or not? A new subpopulation of neurons controls the switch of female sexual behavior. Neuron 110: 2893-2895 (2022)
30. Wei Xiao, Zhuo-Lei Jiao, Esra Senol, Jiwei Yao, Miao Zhao, Zheng-Dong Zhao, Xiaowei Chen, Peng Cao, Yu Fu, Zhihua Gao, Wei L Shen, Xiao-Hong Xu. Neural circuit control of innate behaviors. Science China Life Sciences 65: 466–499 (2022)
31. Xue Liu, Hongren Huang, Terrance P Snutch, Peng Cao, Liping Wang, Feng Wang. The superior colliculus: cell types, connectivity, and behavior. Neuroscience Bulletin 38: 1519–1540 (2022)
