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科學研究

蛋白質組中心

蛋白質組中心

陳涉博士

北京生命科學研究所高級研究員，蛋白質組中心主任

Associate Investigator and Director of?Proteomics?Center, NIBS,Beijing,?China

電話： 010-80726688-8370

E-mail: chenshe@nibs.ac.cn

中心主任介紹：

陳涉研究員1995年于武漢大學獲得生物化學學士學位；1998年于中國科學院生物物理研究所獲得生物物理碩士學位；2000年于美國Iowa State University獲得食品科學碩士學位；2009年于北京師范大學獲得生物化學及分子生物學博士學位。2001年至2004年間分別于美國University of Texas Southwestern Medical Center at Dallas和美國MDS Proteomics Inc.公司從事蛋白質生物質譜技術工作。2004年回國建立北京生命科學研究所蛋白質組中心并工作至今。2015年入選國家百千萬人才工程，并獲得國家有突出貢獻中青年專家稱號?，F(xiàn)任北京生命科學研究所高級研究員，蛋白組中心主任。

陳涉研究員致力于蛋白質生物質譜技術的開發(fā)和應用，將生物質譜技術運用到包括病原體和宿主的相互作用、程序性細胞死亡、真核生物細胞表觀遺傳學信息的傳遞、晝夜節(jié)律的調控等眾多基礎生物學領域，取得了一系列重要成果，并發(fā)表在包括Nature, Science, Cell在內的高水平國際期刊上。

北京生命科學研究所蛋白質組中心簡介:

北京生命科學研究所蛋白質組中心籌建于2004年，中心的核心組成部分為生物質譜實驗室，擁有Orbitrap Fusion Lumos、LTQ Orbitrap Velos、Q Exactive等多臺大型生物質譜儀，為研究所各實驗室提供高質量的生物質譜分析服務。服務內容包括蛋白質和多肽分子量測定，蛋白質的鑒定，蛋白質翻譯后修飾的分析與鑒定，復雜蛋白質混合樣品的分析，以及蛋白質組的比較定量研究。

中心在積極開發(fā)和完善各種先進的生物質譜分析技術的基礎上，致力于將這些技術有效的運用到基礎生物學研究中去，幫助解決基礎生物學研究領域中的各個重大生物學問題。中心廣泛開展合作研究，根據(jù)各個具體生物學問題的需要開發(fā)和完善相應的生物質譜技術，加快這些生物學問題的解決，促進基礎生物學研究領域的發(fā)展。

聯(lián)系方式：

北京生命科學研究所蛋白質組中心

電話：010-80726688轉8372

傳真：010-80727513

地址：北京市昌平區(qū)中關村生命科學園科學園路七號

郵編：102206

中心現(xiàn)有生物質譜儀:

Orbitrap Fusion Lumos質譜儀	Q Exactive質譜儀

LTQ Orbitrap Velos質譜儀

中心部分署名文章:

1. Zhao, Y., Lin, L., Wang, X., He, S., Shi, W., Chen, S. (2022). Temporal Proteomic and Phosphoproteomic Analysis of EV-A71-Infected Human Cells. J. Proteome Res.
(https://doi.org/10.1021/acs.jproteome.2c00237)

2. Li, D., Chen, J., Guo, J., Li, L., Cai, G., Chen, S., Huang, J., Yang, H., Zhuang, Y., Wang, F., and Wang, X. (2021). A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2alpha-induced corpus luteum regression. eLife 10: e67409

3. Lyu, X., Yang, Q., Li, L., Dang, Y., Zhou, Z., Chen, S., and Liu, Y. (2020). Adaptation of codon usage to tRNA I34 modification controls translation kinetics and proteome landscape. PLoS Genet. 16(6): e1008836

4. Yang, Z., Wang, C., Xue, Y., Liu, X., Chen, S., Song, C., Yang, Y., and Guo, Y. (2019). Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance. Nat. Commun. 10(1): 1199

5. Liu, J., Li, M., Li, L., Chen, S., and Wang, X. (2018). Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation. J. Cell Biol. 217(1): 347-360

6. Zhou, Y., Huang, C., Yin, L., Wan, M., Wang, X., Li, L., Liu, Y., Wang, Z., Fu, P., Zhang, N., Chen, S., Liu, X., Shao, F., and Zhu, Y. (2017). N(epsilon)-Fatty acylation of Rho GTPases by a MARTX toxin effector. Science 358(6362): 528-531

7. Zhang, L., Wu, C., Cai, G., Chen, S., and Ye, K. (2016). Stepwise and dynamic assembly of the earliest precursors of small ribosomal subunits in yeast. Genes Dev. 30(6): 718-732

8. Li, D., Xu, T., Cao, Y., Wang, H., Li, L., Chen, S., Wang, X., and Shen, Z. (2015). A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis. Proc. Natl. Acad. Sci. U. S. A. 112(16): 5017-5022

9. Guo, B., Liang, Q., Li, L., Hu, Z., Wu, F., Zhang, P., Ma, Y., Zhao, B., Kovacs, A.L., Zhang, Z., Feng, D., Chen, S., and Zhang, H. (2014). O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation. Nat. Cell Biol. 16(12): 1215-1226

10. Li, S., Zhang, L., Yao, Q., Li, L., Dong, N., Rong, J., Gao, W., Ding, X., Sun, L., Chen, X., Chen, S.^#, and Shao, F.^# (2013). Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains. Nature 501(7466): 242-246. ( ^#共同通訊作者).

11. Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., and Wang, X. (2012). Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase. Cell 148(1-2): 213-227

12. Xu, M., Wang, W., Chen, S.^#, and Zhu, B.^# (2012). A model for mitotic inheritance of histone lysine methylation. EMBO Rep. 13(1): 60-67. (^#共同通訊作者).

13. Zhang, L., Ding, X., Cui, J., Xu, H., Chen, J., Gong, Y. N., Hu, L., Zhou, Y., Ge, J., Lu, Q., Liu, L., Chen, S., and Shao, F. (2011). Cysteine methylation disrupts ubiquitin-chain sensing in NF-kappaB activation. Nature 481(7380): 204-208

14. Shang, L., Chen, S., Du, F., Li, S., Zhao, L., and Wang, X. (2011). Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc. Natl. Acad. Sci. U. S. A. 108(12): 4788-4793

15. Xu, M., Long, C., Chen, X., Huang, C., Chen, S.^#, and Zhu, B.^# (2010). Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly. Science 328(5974): 94-98. (^#共同通訊作者).

16. Cui, J., Yao, Q., Li, S., Ding, X., Lu, Q., Mao, H., Liu, L., Zheng, N., Chen, S., and Shao, F. (2010). Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science 329(5996): 1215-1218

17. Tang, C. T., Li, S., Long, C., Cha, J., Huang, G., Li, L., Chen, S.^#, and Liu, Y.^# (2009). Setting the pace of the Neurospora circadian clock by multiple independent FRQ phosphorylation events. Proc. Natl. Acad. Sci. U. S. A. 106(26): 10722-10727. (^#共同通訊作者).

18. Huang, G.*, Chen, S.*, Li, S., Cha, J., Long, C., Li, L., He, Q., and Liu, Y. (2007). Protein kinase A and casein kinases mediate sequential phosphorylation events in the circadian negative feedback loop. Genes Dev. 21(24): 3283-3295. (*共同第一作者).

中心全部署名文章:

1. Zhu, X., Yang, N., Yang, Y., Yuan, F., Yu, D., Zhang, Y., Shu, Z., Nan, N., Hu, H., Liu, X., Chen, S., Sun, L., and Wang, H. (2022). Spontaneous necroptosis and autoinflammation are blocked by an inhibitory phosphorylation on MLKL during neonatal development. Cell Res. 32(4): 407-410

2. Zhou, J.X., Su, X.M., Zheng, S.Y., Wu, C.J., Su, Y.N., Jiang, Z., Li, L., Chen, S., and He, X.J. (2022). The Arabidopsis NuA4 histone acetyltransferase complex is required for chlorophyll biosynthesis and photosynthesis. J. Integr. Plant Biol. 64(4): 901-914

3. Yan, B., Ding, Z., Zhang, W., Cai, G., Han, H., Ma, Y., Cao, Y., Wang, J., Chen, S., and Ai, Y. (2022). Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death. Cell Chem. Biol. 29(6): 958-969 e955

4. Qi, P.L., Zhou, H.R., Zhao, Q.Q., Feng, C., Ning, Y.Q., Su, Y.N., Cai, X.W., Yuan, D.Y., Zhang, Z.C., Su, X.M., Chen, S.S., Li, L., Chen, S., and He, X.J. (2022). Characterization of an autonomous pathway complex that promotes flowering in Arabidopsis. Nucleic Acids Res. 50(13): 7380-7395

5. Dou, C., Long, Z., Li, S., Zhou, D., Jin, Y., Zhang, L., Zhang, X., Zheng, Y., Li, L., Zhu, X., Liu, Z., He, S., Yan, W., Yang, L., Xiong, J., Fu, X., Qi, S., Ren, H., Chen, S., Dai, L., Wang, B., and Cheng, W. (2022). Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis. Cell Res. 32(3): 302-314

6. Wu, C.J., Liu, Z.Z., Wei, L., Zhou, J.X., Cai, X.W., Su, Y.N., Li, L., Chen, S., and He, X.J. (2021). Three functionally redundant plant-specific paralogs are core subunits of the SAGA histone acetyltransferase complex in Arabidopsis. Mol. Plant 14(7): 1071-1087

7. Tan, M., Li, S., Juillard, F., Chitas, R., Custodio, T.F., Xue, H., Szymula, A., Sun, Q., Liu, B., Alvarez, A.L., Chen, S., Huang, J., Simas, J.P., McVey, C.E., and Kaye, K.M. (2021). MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res. 49(22): 12895-12911

8. Shang, J.Y., Lu, Y.J., Cai, X.W., Su, Y.N., Feng, C., Li, L., Chen, S., and He, X.J. (2021). COMPASS functions as a module of the INO80 chromatin remodeling complex to mediate histone H3K4 methylation in Arabidopsis. Plant Cell 33(10): 3250-3271

9. Qian, F., Zhao, Q.Y., Zhang, T.N., Li, Y.L., Su, Y.N., Li, L., Sui, J.H., Chen, S., and He, X.J. (2021). A histone H3K27me3 reader cooperates with a family of PHD finger-containing proteins to regulate flowering time in Arabidopsis. J. Integr. Plant Biol. 63(4): 787-802

10. Liu, S., Liu, S., He, B., Li, L., Li, L., Wang, J., Cai, T., Chen, S., and Jiang, H. (2021). OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential. EMBO reports 22(4): e51606

11. Li, D., Chen, J., Guo, J., Li, L., Cai, G., Chen, S., Huang, J., Yang, H., Zhuang, Y., Wang, F., and Wang, X. (2021). A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2alpha-induced corpus luteum regression. eLife 10: e67409

12. Hu, X., Li, Y., Zhang, T., Li, L., Chen, S., Wu, X., Li, H., Qi, B., and Chen, Z. (2021). Phosphorylation of Ago2 is required for its role in DNA double-strand break repair. J Genet. Genomics 48(4): 333-340

13. Guo, J., Wei, L., Chen, S.S., Cai, X.W., Su, Y.N., Li, L., Chen, S., and He, X.J. (2021). The CBP/p300 histone acetyltransferases function as plant-specific MEDIATOR subunits in Arabidopsis. J. Integr. Plant Biol. 63(4): 755-771

14. Feng, C., Cai, X.W., Su, Y.N., Li, L., Chen, S., and He, X.J. (2021). Arabidopsis RPD3-like histone deacetylases form multiple complexes involved in stress response. J. Genet. Genomics 48(5): 369-383

15. Ao, K., Tong, M., Li, L., Ludke, D., Lipka, V., Chen, S., Wiermer, M., and Li, X. (2021). SCF(SNIPER7) controls protein turnover of unfoldase CDC48A to promote plant immunity. New Phytol. 229(5): 2795-2811

16. Zhou, S., Zhang, W., Cai, G., Ding, Y., Wei, C., Li, S., Yang, Y., Qin, J., Liu, D., Zhang, H., Shao, X., Wang, J., Wang, H., Yang, W., Wang, H., Chen, S., Hu, P., and Sun, L. (2020). Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration. Cell Res. 30(12): 1063-1077

17. Zhou, H.R., Lin, R.N., Huang, H.W., Li, L., Cai, T., Zhu, J.K., Chen, S., and He, X.J. (2020). The CCR4-NOT complex component NOT1 regulates RNA-directed DNA methylation and transcriptional silencing by facilitating Pol IV-dependent siRNA production. Plant J. 103(4): 1503-1515

18. Tan, L.M., Liu, R., Gu, B.W., Zhang, C.J., Luo, J., Guo, J., Wang, Y., Chen, L., Du, X., Li, S., Shao, C.R., Su, Y.N., Cai, X.W., Lin, R.N., Li, L., Chen, S., Du, J., and He, X.J. (2020). Dual Recognition of H3K4me3 and DNA by the ISWI Component ARID5 Regulates the Floral Transition in Arabidopsis. Plant Cell 32(7): 2178-2195

19. Ning, Y.Q., Liu, N., Lan, K.K., Su, Y.N., Li, L., Chen, S., and He, X.J. (2020). DREAM complex suppresses DNA methylation maintenance genes and precludes DNA hypermethylation. Nat. Plants 6(8): 942-956

20. Lyu, X., Yang, Q., Li, L., Dang, Y., Zhou, Z., Chen, S., and Liu, Y. (2020). Adaptation of codon usage to tRNA I34 modification controls translation kinetics and proteome landscape. PLoS Genet. 16(6): e1008836

21. Luo, Y.X., Hou, X.M., Zhang, C.J., Tan, L.M., Shao, C.R., Lin, R.N., Su, Y.N., Cai, X.W., Li, L., Chen, S., and He, X.J. (2020). A plant-specific SWR1 chromatin-remodeling complex couples histone H2A.Z deposition with nucleosome sliding. EMBO J. 39(7): e102008

22. Li, D., Ai, Y., Guo, J., Dong, B., Li, L., Cai, G., Chen, S., Xu, D., Wang, F., and Wang, X. (2020). Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. eLife 9: e61564

23. Ju, D., Zhang, W., Yan, J., Zhao, H., Li, W., Wang, J., Liao, M., Xu, Z., Wang, Z., Zhou, G., Mei, L., Hou, N., Ying, S., Cai, T., Chen, S., Xie, X., Lai, L., Tang, C., Park, N., Takahashi, J.S., Huang, N., Qi, X., and Zhang, E.E. (2020). Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals. Sci. Transl. Med. 12(542)

24. Johnston, A.N., Ma, Y., Liu, H., Liu, S., Hanna-Addams, S., Chen, S., Chen, C., and Wang, Z. (2020). Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis. Proc. Natl. Acad. Sci. U. S. A. 117(12): 6521-6530

25. Jiang, Z., Jin, X., Li, Y., Liu, S., Liu, X.M., Wang, Y.Y., Zhao, P., Cai, X., Liu, Y., Tang, Y., Sun, X., Liu, Y., Hu, Y., Li, M., Cai, G., Qi, X., Chen, S., Du, L.L., and He, W. (2020). Genetically encoded tags for direct synthesis of EM-visible gold nanoparticles in cells. Nat. Methods 17(9): 937-946

26. Jiang, X., Wang, X., Ding, X., Du, M., Li, B., Weng, X., Zhang, J., Li, L., Tian, R., Zhu, Q., Chen, S., Wang, L., Liu, W., Fang, L., Neculai, D., and Sun, Q. (2020). FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy. EMBO J. 39(5): e102608

27. Hanna-Addams, S., Liu, S., Liu, H., Chen, S., and Wang, Z. (2020). CK1alpha, CK1delta, and CK1epsilon are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis. Proc. Natl. Acad. Sci. U. S. A. 117(4): 1962-1970

28. Gu, B.W., Tan, L.M., Zhang, C.J., Hou, X.M., Cai, X.W., Chen, S., and He, X.J. (2020). FHA2 is a plant-specific ISWI subunit responsible for stamen development and plant fertility. J. Integr. Plant Biol. 62(11): 1703-1716

29. Gao, L., Su, C., Du, X., Wang, R., Chen, S., Zhou, Y., Liu, C., Liu, X., Tian, R., Zhang, L., Xie, K., Chen, S., Guo, Q., Guo, L., Hano, Y., Shimazaki, M., Minami, A., Oikawa, H., Huang, N., Houk, K.N., Huang, L., Dai, J., and Lei, X. (2020). FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis. Nat. Chem. 12(7): 620-628

30. Zhu, W., Li, J., Zhang, R., Cai, Y., Wang, C., Qi, S., Chen, S., Liang, X., Qi, N., and Hou, F. (2019). TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity. EMBO J. 38(18): e102075

31. Zhao, Q.Q., Lin, R.N., Li, L., Chen, S., and He, X.J. (2019). A methylated-DNA-binding complex required for plant development mediates transcriptional activation of promoter methylated genes. J. Integr. Plant Biol. 61(2): 120-139

32. Yang, Z., Wang, C., Xue, Y., Liu, X., Chen, S., Song, C., Yang, Y., and Guo, Y. (2019). Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance. Nat. Commun. 10(1): 1199

33. Ning, Y.Q., Chen, Q., Lin, R.N., Li, Y.Q., Li, L., Chen, S., and He, X.J. (2019). The HDA19 histone deacetylase complex is involved in the regulation of flowering time in a photoperiod-dependent manner. Plant J. 98(3): 448-464

34. Li, D., Chen, J., Ai, Y., Gu, X., Li, L., Che, D., Jiang, Z., Li, L., Chen, S., Huang, H., Wang, J., Cai, T., Cao, Y., Qi, X., and Wang, X. (2019). Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover. Mol. Cell 75(6): 1103-1116 e1109

35. Fan, W., Guo, J., Gao, B., Zhang, W., Ling, L., Xu, T., Pan, C., Li, L., Chen, S., Wang, H., Zhang, J., and Wang, X. (2019). Flotillin-mediated endocytosis and ALIX-syntenin-1-mediated exocytosis protect the cell membrane from damage caused by necroptosis. Sci. Signal. 12(583)

36. Ding, X., Jiang, X., Tian, R., Zhao, P., Li, L., Wang, X., Chen, S., Zhu, Y., Mei, M., Bao, S., Liu, W., Tang, Z., and Sun, Q. (2019). RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. Autophagy 15(10): 1774-1786

37. Cheng, X., Ma, X., Zhu, Q., Song, D., Ding, X., Li, L., Jiang, X., Wang, X., Tian, R., Su, H., Shen, Z., Chen, S., Liu, T., Gong, W., Liu, W., and Sun, Q. (2019). Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism. Mol. Cell 73(4): 788-802 e787

38. Zhou, J.X., Liu, Z.W., Li, Y.Q., Li, L., Wang, B., Chen, S., and He, X.J. (2018). Arabidopsis PWWP domain proteins mediate H3K27 trimethylation on FLC and regulate flowering time. J. Integr. Plant Biol. 60(5): 362-368

39. Ying, Z., Pan, C., Shao, T., Liu, L., Li, L., Guo, D., Zhang, S., Yuan, T., Cao, R., Jiang, Z., Chen, S., Wang, F., and Wang, X. (2018). Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury. Mol. Cell 72(3): 457-468 e455

40. Wang, J., Grubb, L.E., Wang, J., Liang, X., Li, L., Gao, C., Ma, M., Feng, F., Li, M., Li, L., Zhang, X., Yu, F., Xie, Q., Chen, S., Zipfel, C., Monaghan, J., and Zhou, J.M. (2018). A Regulatory Module Controlling Homeostasis of a Plant Immune Kinase. Mol. Cell 69(3): 493-504 e496

41. Tan, L.M., Zhang, C.J., Hou, X.M., Shao, C.R., Lu, Y.J., Zhou, J.X., Li, Y.Q., Li, L., Chen, S., and He, X.J. (2018). The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing. EMBO J. 37(19)

42. Qin, J., Wang, K., Sun, L., Xing, H., Wang, S., Li, L., Chen, S., Guo, H.S., and Zhang, J. (2018). The plant-specific transcription factors CBP60g and SARD1 are targeted by a Verticillium secretory protein VdSCP41 to modulate immunity. eLife 7: e34902

43. Qi, C., Wang, X., Shen, Z., Chen, S., Yu, H., Williams, N., and Wang, G. (2018). Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells. Cell Res. 28(5): 544-555

44. Luo, Y.X., Han, Y.F., Zhao, Q.Y., Du, J.L., Dou, K., Li, L., Chen, S., and He, X.J. (2018). Sumoylation of SUVR2 contributes to its role in transcriptional gene silencing. Science China. Life sciences 61(2): 235-243

45. Liu, W., Zhou, Y., Peng, T., Zhou, P., Ding, X., Li, Z., Zhong, H., Xu, Y., Chen, S., Hang, H.C., and Shao, F. (2018). N(epsilon)-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function. Nat. Microbiol. 3(9): 996-1009

46. Liu, J., Li, M., Li, L., Chen, S., and Wang, X. (2018). Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation. J. Cell Biol. 217(1): 347-360

47. Liang, X., Ma, M., Zhou, Z., Wang, J., Yang, X., Rao, S., Bi, G., Li, L., Zhang, X., Chai, J., Chen, S., and Zhou, J.M. (2018). Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases. Cell Res. 28(5): 529-543

48. Dong, O.X., Ao, K., Xu, F., Johnson, K.C.M., Wu, Y., Li, L., Xia, S., Liu, Y., Huang, Y., Rodriguez, E., Chen, X., Chen, S., Zhang, Y., Petersen, M., and Li, X. (2018). Individual components of paired typical NLR immune receptors are regulated by distinct E3 ligases. Nat. Plants 4(9): 699-710

49. Bi, G., Zhou, Z., Wang, W., Li, L., Rao, S., Wu, Y., Zhang, X., Menke, F.L.H., Chen, S., and Zhou, J.M. (2018). Receptor-Like Cytoplasmic Kinases Directly Link Diverse Pattern Recognition Receptors to the Activation of Mitogen-Activated Protein Kinase Cascades in Arabidopsis. Plant Cell 30(7): 1543-1561

50. Aharoni-Kats, L., Zelinger, E., Chen, S., and Yarden, O. (2018). Altering Neurospora crassa MOB2A exposes its functions in development and affects its interaction with the NDR kinase COT1. Mol. Microbiol. 108(6): 641-660

51. Zhou, Y., Huang, C., Yin, L., Wan, M., Wang, X., Li, L., Liu, Y., Wang, Z., Fu, P., Zhang, N., Chen, S., Liu, X., Shao, F., and Zhu, Y. (2017). N(epsilon)-Fatty acylation of Rho GTPases by a MARTX toxin effector. Science 358(6362): 528-531

52. Zhao, Y.G., Chen, Y., Miao, G., Zhao, H., Qu, W., Li, D., Wang, Z., Liu, N., Li, L., Chen, S., Liu, P., Feng, D., and Zhang, H. (2017). The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Mol. Cell 67(6): 974-989 e976

53. Yi, C., Tong, J., Lu, P., Wang, Y., Zhang, J., Sun, C., Yuan, K., Xue, R., Zou, B., Li, N., Xiao, S., Dai, C., Huang, Y., Xu, L., Li, L., Chen, S., Miao, D., Deng, H., Li, H., and Yu, L. (2017). Formation of a Snf1-Mec1-Atg1 Module on Mitochondria Governs Energy Deprivation-Induced Autophagy by Regulating Mitochondrial Respiration. Dev. Cell 41(1): 59-71 e54

54. Yan, B., Liu, L., Huang, S., Ren, Y., Wang, H., Yao, Z., Li, L., Chen, S., Wang, X., and Zhang, Z. (2017). Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein. Chem. Commun. 53(26): 3637-3640

55. Wang, B., Chen, X., Wang, Z., Xiong, W., Xu, T., Zhao, X., Cao, Y., Guo, Y., Li, L., Chen, S., Huang, S., Wang, X., Fang, M., and Shen, Z. (2017). Aldehyde dehydrogenase 1A1 increases NADH levels and promotes tumor growth via glutathione/dihydrolipoic acid-dependent NAD(+) reduction. Oncotarget 8(40): 67043-67055

56. Shi, Y., Yuan, B., Zhu, W., Zhang, R., Li, L., Hao, X., Chen, S., and Hou, F. (2017). Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity. Nat. Commun. 8: 15138

57. Reynoso, E., Liu, H., Li, L., Yuan, A.L., Chen, S., and Wang, Z. (2017). Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis. J. Biol. Chem. 292(42): 17514-17524

58. Ma, X., Zhang, S., He, L., Rong, Y., Brier, L.W., Sun, Q., Liu, R., Fan, W., Chen, S., Yue, Z., Kim, J., Guan, K.L., Li, D., and Zhong, Q. (2017). MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy. Autophagy 13(3): 592-607

59. Huang, C., Yang, F., Zhang, Z., Zhang, J., Cai, G., Li, L., Zheng, Y., Chen, S., Xi, R., and Zhu, B. (2017). Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila. Nat. Commun. 8(1): 1649

60. Gao, Y., Liu, X., Tang, B., Li, C., Kou, Z., Li, L., Liu, W., Wu, Y., Kou, X., Li, J., Zhao, Y., Yin, J., Wang, H., Chen, S., Liao, L., and Gao, S. (2017). Protein Expression Landscape of Mouse Embryos during Pre-implantation Development. Cell Rep. 21(13): 3957-3969

61. Fan, J., Kuai, B., Wu, G., Wu, X., Chi, B., Wang, L., Wang, K., Shi, Z., Zhang, H., Chen, S., He, Z., Wang, S., Zhou, Z., Li, G., and Cheng, H. (2017). Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export. EMBO J. 36(19): 2870-2886

62. Cheng, X., Ma, X., Ding, X., Li, L., Jiang, X., Shen, Z., Chen, S., Liu, W., Gong, W., and Sun, Q. (2017). Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17. Mol. Cell 65(6): 1029-1043 e1025

63. Zhuang, N., Li, L., Chen, S., and Wang, T. (2016). PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control. Cell Death Dis. 7(12): e2501

64. Zhang, L., Wu, C., Cai, G., Chen, S., and Ye, K. (2016). Stepwise and dynamic assembly of the earliest precursors of small ribosomal subunits in yeast. Genes Dev. 30(6): 718-732

65. Zhang, C.J., Hou, X.M., Tan, L.M., Shao, C.R., Huang, H.W., Li, Y.Q., Li, L., Cai, T., Chen, S., and He, X.J. (2016). The Arabidopsis acetylated histone-binding protein BRAT1 forms a complex with BRP1 and prevents transcriptional silencing. Nat. Commun. 7: 11715

66. Yun, T., Yu, K., Yang, S., Cui, Y., Wang, Z., Ren, H., Chen, S., Li, L., Liu, X., Fang, M., and Jiang, X. (2016). Acetylation of p53 Protein at Lysine 120 Up-regulates Apaf-1 Protein and Sensitizes the Mitochondrial Apoptotic Pathway. J. Biol. Chem. 291(14): 7386-7395

67. Xiong, J., Zhang, Z., Chen, J., Huang, H., Xu, Y., Ding, X., Zheng, Y., Nishinakamura, R., Xu, G.L., Wang, H., Chen, S., Gao, S., and Zhu, B. (2016). Cooperative Action between SALL4A and TET Proteins in Stepwise Oxidation of 5-Methylcytosine. Mol. Cell 64(5): 913-925

68. Wang, Z., Dang, T., Liu, T., Chen, S., Li, L., Huang, S., and Fang, M. (2016). NEDD4L Protein Catalyzes Ubiquitination of PIK3CA Protein and Regulates PI3K-AKT Signaling. J. Biol. Chem. 291(33): 17467-17477

69. Sun, H., Ren, Y., Hou, W., Li, L., Zeng, F., Li, S., Ma, Y., Liu, X., Chen, S., and Zhang, Z. (2016). Focusing on probe-modified peptides: a quick and effective method for target identification. Chem. Commun. 52(67): 10225-10228

70. Ren, J., Zhang, M.J., Li, T.M., Zhang, J.E., Lin, R., Chen, S., Luo, M., and Dong, M.Q. (2016). Quantitative Proteomics of Sleep-Deprived Mouse Brains Reveals Global Changes in Mitochondrial Proteins. PloS one 11(9): e0163500

71. Liu, Z.W., Zhou, J.X., Huang, H.W., Li, Y.Q., Shao, C.R., Li, L., Cai, T., Chen, S., and He, X.J. (2016). Two Components of the RNA-Directed DNA Methylation Pathway Associate with MORC6 and Silence Loci Targeted by MORC6 in Arabidopsis. PLoS Genet. 12(5): e1006026

72. Liu, Y., Yang, H., Li, L., Chen, S., Zuo, F., and Chen, L. (2016). A novel VHLalpha isoform inhibits Warburg effect via modulation of PKM splicing. Tumour Biol. 37(10): 13649-13657

73. Liang, X., Ding, P., Lian, K., Wang, J., Ma, M., Li, L., Li, M., Zhang, X., Chen, S., Zhang, Y., and Zhou, J.M. (2016). Arabidopsis heterotrimeric G proteins regulate immunity by directly coupling to the FLS2 receptor. eLife 5: e13568

74. Li, L., Kim, P., Yu, L., Cai, G., Chen, S., Alfano, J.R., and Zhou, J.M. (2016). Activation-Dependent Destruction of a Co-receptor by a Pseudomonas syringae Effector Dampens Plant Immunity. Cell Host Microbe 20(4): 504-514

75. Li, D., Li, C., Li, L., Chen, S., Wang, L., Li, Q., Wang, X., Lei, X., and Shen, Z. (2016). Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis. Cell Chem. Biol. 23(2): 257-266

76. Jiang, X., Li, L., Ying, Z., Pan, C., Huang, S., Dai, M., Yan, B., Li, M., Jiang, H., Chen, S., Zhang, Z., and Wang, X. (2016). A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway. Mol. Cell 63(2): 229-239

77. Han, Y.F., Zhao, Q.Y., Dang, L.L., Luo, Y.X., Chen, S.S., Shao, C.R., Huang, H.W., Li, Y.Q., Li, L., Cai, T., Chen, S., and He, X.J. (2016). The SUMO E3 Ligase-Like Proteins PIAL1 and PIAL2 Interact with MOM1 and Form a Novel Complex Required for Transcriptional Silencing. Plant Cell 28(5): 1215-1229

78. Dong, T., Liu, W., Shen, Z., Li, L., Chen, S., and Lei, X. (2016). Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain. Sci. Rep. 6: 19231

79. Aubert, D.F., Xu, H., Yang, J., Shi, X., Gao, W., Li, L., Bisaro, F., Chen, S., Valvano, M.A., and Shao, F. (2016). A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation. Cell Host Microbe 19(5): 664-674

80. Zhang, X., Dong, T., Li, Q., Liu, X., Li, L., Chen, S., and Lei, X. (2015). Second Generation TQ-Ligation for Cell Organelle Imaging. ACS Chem. Biol. 10(7): 1676-1683

81. Zhang, H., Cao, J., Li, L., Liu, Y., Zhao, H., Li, N., Li, B., Zhang, A., Huang, H., Chen, S., Dong, M., Yu, L., Zhang, J., and Chen, L. (2015). Identification of urine protein biomarkers with the potential for early detection of lung cancer. Sci. Rep. 5: 11805

82. Xu, F., Huang, Y., Li, L., Gannon, P., Linster, E., Huber, M., Kapos, P., Bienvenut, W., Polevoda, B., Meinnel, T., Hell, R., Giglione, C., Zhang, Y., Wirtz, M., Chen, S., and Li, X. (2015). Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. Plant Cell 27(5): 1547-1562

83. Wang, G., Roux, B., Feng, F., Guy, E., Li, L., Li, N., Zhang, X., Lautier, M., Jardinaud, M.F., Chabannes, M., Arlat, M., Chen, S., He, C., Noel, L.D., and Zhou, J.M. (2015). The Decoy Substrate of a Pathogen Effector and a Pseudokinase Specify Pathogen-Induced Modified-Self Recognition and Immunity in Plants. Cell Host Microbe 18(3): 285-295

84. Shi, M., Zhang, H., Wang, L., Zhu, C., Sheng, K., Du, Y., Wang, K., Dias, A., Chen, S., Whitman, M., Wang, E., Reed, R., and Cheng, H. (2015). Premature termination codons are recognized in the nucleus in a reading-frame-dependent manner. Cell Discov. 1: 15001

85. Ning, Y.Q., Ma, Z.Y., Huang, H.W., Mo, H., Zhao, T.T., Li, L., Cai, T., Chen, S., Ma, L., and He, X.J. (2015). Two novel NAC transcription factors regulate gene expression and flowering time by associating with the histone demethylase JMJ14. Nucleic Acids Res. 43(3): 1469-1484

86. Liu, N., Zhang, Z., Wu, H., Jiang, Y., Meng, L., Xiong, J., Zhao, Z., Zhou, X., Li, J., Li, H., Zheng, Y., Chen, S., Cai, T., Gao, S., and Zhu, B. (2015). Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability. Genes Dev. 29(4): 379-393

87. Li, J., Liu, J., Wang, G., Cha, J.Y., Li, G., Chen, S., Li, Z., Guo, J., Zhang, C., Yang, Y., Kim, W.Y., Yun, D.J., Schumaker, K.S., Chen, Z., and Guo, Y. (2015). A Chaperone Function of NO CATALASE ACTIVITY1 Is Required to Maintain Catalase Activity and for Multiple Stress Responses in Arabidopsis. Plant Cell 27(3): 908-925

88. Li, D., Xu, T., Cao, Y., Wang, H., Li, L., Chen, S., Wang, X., and Shen, Z. (2015). A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis. Proc. Natl. Acad. Sci. U. S. A. 112(16): 5017-5022

89. Kang, S., Yang, F., Li, L., Chen, H., Chen, S., and Zhang, J. (2015). The Arabidopsis Transcription Factor BRASSINOSTEROID INSENSITIVE1-ETHYL METHANESULFONATE-SUPPRESSOR1 Is a Direct Substrate of MITOGEN-ACTIVATED PROTEIN KINASE6 and Regulates Immunity. Plant Physiol. 167(3): 1076-1086

90. Hu, Z., Wan, X., Hao, R., Zhang, H., Li, L., Xie, Q., Wang, P., Gao, Y., Chen, S., Wei, M., Luan, Z., Zhang, A., Huang, N., and Chen, L. (2015). Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity. PloS one 10(4): e0123623

91. Han, Y.F., Huang, H.W., Li, L., Cai, T., Chen, S., and He, X.J. (2015). The Cytosolic Iron-Sulfur Cluster Assembly Protein MMS19 Regulates Transcriptional Gene Silencing, DNA Repair, and Flowering Time in Arabidopsis. PloS one 10(6): e0129137

92. Feng, W., Wu, T., Dan, X., Chen, Y., Li, L., Chen, S., Miao, D., Deng, H., Gong, X., and Yu, L. (2015). Phosphorylation of Atg31 is required for autophagy. Protein Cell 6(4): 288-296

93. Du, J.L., Zhang, S.W., Huang, H.W., Cai, T., Li, L., Chen, S., and He, X.J. (2015). The Splicing Factor PRP31 Is Involved in Transcriptional Gene Silencing and Stress Response in Arabidopsis. Mol. Plant 8(7): 1053-1068

94. Dong, T., Li, C., Wang, X., Dian, L., Zhang, X., Li, L., Chen, S., Cao, R., Huang, N., He, S., and Lei, X. (2015). Ainsliadimer A selectively inhibits IKKalpha/beta by covalently binding a conserved cysteine. Nat. Commun. 6: 6522

95. Zhou, H., Lin, H., Chen, S., Becker, K., Yang, Y., Zhao, J., Kudla, J., Schumaker, K.S., and Guo, Y. (2014). Inhibition of the Arabidopsis Salt Overly Sensitive Pathway by 14-3-3 Proteins. Plant Cell 26(3): 1166-1182

96. Zhang, Z., Yang, Q., Sun, G., Chen, S., He, Q., Li, S., and Liu, Y. (2014). Histone H3K56 acetylation is required for quelling-induced small RNA production through its role in homologous recombination. J. Biol. Chem. 289(13): 9365-9371

97. Yao, Q., Zhang, L., Wan, X., Chen, J., Hu, L., Ding, X., Li, L., Karar, J., Peng, H., Chen, S., Huang, N., Rauscher, F.J., 3rd, and Shao, F. (2014). Structure and specificity of the bacterial cysteine methyltransferase effector NleE suggests a novel substrate in human DNA repair pathway. PLoS Pathog. 10(11): e1004522

98. Xu, H., Yang, J., Gao, W., Li, L., Li, P., Zhang, L., Gong, Y.N., Peng, X., Xi, J.J., Chen, S., Wang, F., and Shao, F. (2014). Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature 513(7517): 237-241

99. Wang, X., Li, Y., Liu, S., Yu, X., Li, L., Shi, C., He, W., Li, J., Xu, L., Hu, Z., Yu, L., Yang, Z., Chen, Q., Ge, L., Zhang, Z., Zhou, B., Jiang, X., Chen, S., and He, S. (2014). Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense. Proc. Natl. Acad. Sci. U. S. A. 111(43): 15438-15443

100. Sun, Q., Tsurimoto, T., Juillard, F., Li, L., Li, S., De Leon Vazquez, E., Chen, S., and Kaye, K. (2014). Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence. Proc. Natl. Acad. Sci. U. S. A. 111(32): 11816-11821

101. Mao, Z., Pan, L., Wang, W., Sun, J., Shan, S., Dong, Q., Liang, X., Dai, L., Ding, X., Chen, S., Zhang, Z., Zhu, B., and Zhou, Z. (2014). Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.Z. Cell Res. 24(4): 389-399

102. Lu, Q., Yao, Q., Xu, Y., Li, L., Li, S., Liu, Y., Gao, W., Niu, M., Sharon, M., Ben-Nissan, G., Zamyatina, A., Liu, X., Chen, S., and Shao, F. (2014). An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis. Cell Host Microbe 16(3): 351-363

103. Liu, Z.W., Shao, C.R., Zhang, C.J., Zhou, J.X., Zhang, S.W., Li, L., Chen, S., Huang, H.W., Cai, T., and He, X.J. (2014). The SET domain proteins SUVH2 and SUVH9 are required for Pol V occupancy at RNA-directed DNA methylation loci. PLoS Genet. 10(1): e1003948

104. Li, L., Li, M., Yu, L., Zhou, Z., Liang, X., Liu, Z., Cai, G., Gao, L., Zhang, X., Wang, Y., Chen, S., and Zhou, J.M. (2014). The FLS2-associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity. Cell Host Microbe 15(3): 329-338

105. Lan, N., Zhang, H., Hu, C., Wang, W., Calvo, A.M., Harris, S.D., Chen, S., and Li, S. (2014). Coordinated and distinct functions of velvet proteins in Fusarium verticillioides. Eukaryot. Cell 13(7): 909-918

106. Kong, X.D., Yuan, S., Li, L., Chen, S., Xu, J.H., and Zhou, J. (2014). Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates. Proc. Natl. Acad. Sci. U. S. A. 111(44): 15717-15722

107. Han, Y.F., Dou, K., Ma, Z.Y., Zhang, S.W., Huang, H.W., Li, L., Cai, T., Chen, S., Zhu, J.K., and He, X.J. (2014). SUVR2 is involved in transcriptional gene silencing by associating with SNF2-related chromatin-remodeling proteins in Arabidopsis. Cell Res. 24(12): 1445-1465

108. Guo, B., Liang, Q., Li, L., Hu, Z., Wu, F., Zhang, P., Ma, Y., Zhao, B., Kovacs, A.L., Zhang, Z., Feng, D., Chen, S., and Zhang, H. (2014). O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation. Nat. Cell Biol. 16(12): 1215-1226

109. Garg, A., O'Rourke, J., Long, C., Doering, J., Ravenscroft, G., Bezprozvannaya, S., Nelson, B.R., Beetz, N., Li, L., Chen, S., Laing, N.G., Grange, R.W., Bassel-Duby, R., and Olson, E.N. (2014). KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy. J. Clin. Invest. 124(8): 3529-3539

110. Chi, B., Wang, K., Du, Y., Gui, B., Chang, X., Wang, L., Fan, J., Chen, S., Wu, X., Li, G., et al. (2014). A Sub-Element in PRE enhances nuclear export of intronless mRNAs by recruiting the TREX complex via ZC3H18. Nucleic Acids Res. 42(11): 7305-7318

111. Zhou, M., Guo, J., Cha, J., Chae, M., Chen, S., Barral, J. M., Sachs, M. S., and Liu, Y. (2013). Non-optimal codon usage affects expression, structure and function of clock protein FRQ. Nature 495(7439): 111-115

112. Yuan, G., Ma, B., Yuan, W., Zhang, Z., Chen, P., Ding, X., Feng, L., Shen, X., Chen, S., Li, G., and Zhu, B. (2013). Histone H2A ubiquitination inhibits the enzymatic activity of H3 lysine 36 methyltransferases. J. Biol. Chem. 288(43): 30832-30842

113. Xia, S., Cheng, Y. T., Huang, S., Win, J., Soards, A., Jinn, T. L., Jones, J. D., Kamoun, S., Chen, S., Zhang, Y., and Li, X. (2013). Regulation of transcription of nucleotide-binding leucine-rich repeat-encoding genes SNC1 and RPP4 via H3K4 trimethylation. Plant Physiol. 162(3): 1694-1705

114. Wang, G., Wang, X., Yu, H., Wei, S., Williams, N., Holmes, D. L., Halfmann, R., Naidoo, J., Wang, L., Li, L., Chen, S., Harran, P., and Lei, X. (2013). Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat. Chem. Biol. 9(2): 84-89

115. Tang, Z., Lin, M. G., Stowe, T. R., Chen, S., Zhu, M., Stearns, T., Franco, B., and Zhong, Q. (2013). Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites. Nature 502(7470): 254-257

116. Liu, Z., Wu, Y., Yang, F., Zhang, Y., Chen, S., Xie, Q., Tian, X., and Zhou, J. M. (2013). BIK1 interacts with PEPRs to mediate ethylene-induced immunity. Proc. Natl. Acad. Sci. U. S. A. 110(15): 6205-6210

117. Lin, S., Yan, H., Li, L., Yang, M., Peng, B., Chen, S., Li, W., and Chen, P. R. (2013). Site-specific engineering of chemical functionalities on the surface of live hepatitis D virus. Angew. Chem. Int. Ed. Engl. 52(52): 13970-13974

118. Liang, B., Peng, P., Chen, S., Li, L., Zhang, M., Cao, D., Yang, J., Li, H., Gui, T., Li, X., and Shen, K. (2013). Characterization and proteomic analysis of ovarian cancer-derived exosomes. J. proteomics 80C: 171-182

119. Li, T. M., Chen, J., Li, X., Ding, X. J., Wu, Y., Zhao, L. F., Chen, S., Lei, X., and Dong, M. Q. (2013). Absolute quantification of a steroid hormone that regulates development in Caenorhabditis elegans. Anal. Chem. 85(19): 9281-9287

120. Li, S., Zhang, L., Yao, Q., Li, L., Dong, N., Rong, J., Gao, W., Ding, X., Sun, L., Chen, X., Chen, S.^#, and Shao, F.^# (2013). Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains. Nature 501(7466): 242-246. ( ^#共同通訊作者).

121. Zhang, C. J., Ning, Y. Q., Zhang, S. W., Chen, Q., Shao, C. R., Guo, Y. W., Zhou, J. X., Li, L., Chen, S., and He, X. J. (2012). IDN2 and its paralogs form a complex required for RNA-directed DNA methylation. PLoS Genet. 8(5): e1002693

122. Yang, H., Han, Z., Cao, Y., Fan, D., Li, H., Mo, H., Feng, Y., Liu, L., Wang, Z., Yue, Y., Cui, S., Chen, S., Chai, J., and Ma, L. (2012). A companion cell-dominant and developmentally regulated H3K4 demethylase controls flowering time in Arabidopsis via the repression of FLC expression. PLoS Genet. 8(4): e1002664

123. Yang, B., Wu, Y. J., Zhu, M., Fan, S. B., Lin, J., Zhang, K., Li, S., Chi, H., Li, Y. X., Chen, H. F., Luo, S. K., Ding, Y. H., Wang, L. H., Hao, Z., Xiu, L. Y., Chen, S., Ye, K., He, S. M., and Dong, M. Q. (2012). Identification of cross-linked peptides from complex samples. Nat. Methods 9(9): 904-906

124. Xu, M., Wang, W., Chen, S.^#, and Zhu, B.^# (2012). A model for mitotic inheritance of histone lysine methylation. EMBO Rep. 13(1): 60-67. (^#共同通訊作者).

125. Xu, M., Chen, S.^#, and Zhu, B.^#(2012). Investigating the cell cycle-associated dynamics of histone modifications using quantitative mass spectrometry. Methods Enzymol. 512: 29-55. (^#共同通訊作者).

126. Wang, Z., Jiang, H., Chen, S., Du, F., and Wang, X. (2012). The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways. Cell 148(1-2): 228-243

127. Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., and Wang, X. (2012). Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase. Cell 148(1-2): 213-227

128. Rong, Y., Liu, M., Ma, L., Du, W., Zhang, H., Tian, Y., Cao, Z., Li, Y., Ren, H., Zhang, C., Li, L., Chen, S., Xi, J., and Yu, L. (2012). Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation. Nat. Cell Biol. 14(9): 924-934

129. Lee, A. Y., Chen, W., Stippec, S., Self, J., Yang, F., Ding, X., Chen, S., Juang, Y. C., and Cobb, M. H. (2012). Protein kinase WNK3 regulates the neuronal splicing factor Fox-1. Proc. Natl. Acad. Sci. U. S. A. 109(42): 16841-16846

130. Kong, Q., Qu, N., Gao, M., Zhang, Z., Ding, X., Yang, F., Li, Y., Dong, O. X., Chen, S., Li, X., and Zhang, Y. (2012). The MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates immunity mediated by a mitogen-activated protein kinase kinase kinase in Arabidopsis. Plant Cell 24(5): 2225-2236

131. Kato, M., Han, T. W., Xie, S., Shi, K., Du, X., Wu, L. C., Mirzaei, H., Goldsmith, E. J., Longgood, J., Pei, J., Grishin, N. V., Frantz, D. E., Schneider, J. W., Chen, S., Li, L., Sawaya, M. R., Eisenberg, D., Tycko, R., and McKnight, S. L. (2012). Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell 149(4): 753-767

132. Feng, F., Yang, F., Rong, W., Wu, X., Zhang, J., Chen, S., He, C., and Zhou, J. M. (2012). A Xanthomonas uridine 5'-monophosphate transferase inhibits plant immune kinases. Nature 485(7396): 114-118

133. Chen, D., Fan, W., Lu, Y., Ding, X., Chen, S., and Zhong, Q. (2012). A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. Mol. Cell 45(5): 629-641

134. Zhang, L., Ding, X., Cui, J., Xu, H., Chen, J., Gong, Y. N., Hu, L., Zhou, Y., Ge, J., Lu, Q., Liu, L., Chen, S., and Shao, F. (2011). Cysteine methylation disrupts ubiquitin-chain sensing in NF-kappaB activation. Nature 481(7380): 204-208

135. Yuan, W., Xu, M., Huang, C., Liu, N., Chen, S., and Zhu, B. (2011). H3K36 methylation antagonizes PRC2-mediated H3K27 methylation. J. Biol. Chem. 286(10): 7983-7989

136. Ye, X., Huang, N., Liu, Y., Paroo, Z., Huerta, C., Li, P., Chen, S., Liu, Q., and Zhang, H. (2011). Structure of C3PO and mechanism of human RISC activation. Nat. Struct. Mol. Biol. 18(6): 650-657

137. Yang, P., Wang, Y., Chen, J., Li, H., Kang, L., Zhang, Y., Chen, S., Zhu, B., and Gao, S. (2011). RCOR2 is a subunit of the LSD1 complex that regulates ESC property and substitutes for SOX2 in reprogramming somatic cells to pluripotency. Stem Cells 29(5): 791-801

138. Xing, X. F., Li, H., Zhong, X. Y., Zhang, L. H., Wang, X. H., Liu, Y. Q., Jia, S. Q., Shi, T., Niu, Z. J., Peng, Y., Du, H., Zhang, G. G., Hu, Y., Lu, A. P., Li, J. Y., Chen, S., and Ji, J. F. (2011). Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer. Histopathology 59(2): 198-206

139. Wu, H., Chen, X., Xiong, J., Li, Y., Li, H., Ding, X., Liu, S., Chen, S., Gao, S., and Zhu, B. (2011). Histone methyltransferase G9a contributes to H3K27 methylation in vivo. Cell Res. 21(2): 365-367

140. Wang, W., Chen, Z., Mao, Z., Zhang, H., Ding, X., Chen, S., Zhang, X., Xu, R., and Zhu, B. (2011). Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes. EMBO Rep. 12(11): 1160-1166

141. Sun, Q., Zhang, J., Fan, W., Wong, K. N., Ding, X., Chen, S., and Zhong, Q. (2011). The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression. J. Biol. Chem. 286(1): 185-191

142. Shang, L., Chen, S., Du, F., Li, S., Zhao, L., and Wang, X. (2011). Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc. Natl. Acad. Sci. U. S. A. 108(12): 4788-4793

143. Liu, Y., Tan, H., Tian, H., Liang, C., Chen, S., and Liu, Q. (2011). Autoantigen La Promotes Efficient RNAi, Antiviral Response, and Transposon Silencing by Facilitating Multiple-Turnover RISC Catalysis. Mol. Cell 44(3): 502-508

144. Kar, A., Fushimi, K., Zhou, X., Ray, P., Shi, C., Chen, X., Liu, Z., Chen, S., and Wu, J. Y. (2011). RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site. Mol. Cell. Biol. 31(9): 1812-1821

145. Du, W., Lin, H., Chen, S., Wu, Y., Zhang, J., Fuglsang, A. T., Palmgren, M. G., Wu, W., and Guo, Y. (2011). Phosphorylation of SOS3-like calcium-binding proteins by their interacting SOS2-like protein kinases is a common regulatory mechanism in Arabidopsis. Plant Physiol. 156(4): 2235-2243

146. Chen, X., Xiong, J., Xu, M., Chen, S.^#, and Zhu, B.^# (2011). Symmetrical modification within a nucleosome is not required globally for histone lysine methylation. EMBO Rep. 12(3): 244-251. (^#共同通訊作者).

147. Zhang, J., Li, W., Xiang, T., Liu, Z., Laluk, K., Ding, X., Zou, Y., Gao, M., Zhang, X., Chen, S., Mengiste, T., Zhang, Y., and Zhou, J. M. (2010). Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. Cell Host Microbe 7(4): 290-301

148. Xu, M., Long, C., Chen, X., Huang, C., Chen, S.^#, and Zhu, B.^# (2010). Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly. Science 328(5974): 94-98. (^#共同通訊作者).

149. Wang, Y., Li, J., Hou, S., Wang, X., Li, Y., Ren, D., Chen, S., Tang, X., and Zhou, J. M. (2010). A Pseudomonas syringae ADP-ribosyltransferase inhibits Arabidopsis mitogen-activated protein kinase kinases. Plant Cell 22(6): 2033-2044

150. Fang, M., Shen, Z., Huang, S., Zhao, L., Chen, S., Mak, T. W., and Wang, X. (2010). The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell 143(5): 711-724

151. Fan, W., Tang, Z., Chen, D., Moughon, D., Ding, X., Chen, S., Zhu, M., and Zhong, Q. (2010). Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy 6(5): 614-621

152. Cui, J., Yao, Q., Li, S., Ding, X., Lu, Q., Mao, H., Liu, L., Zheng, N., Chen, S., and Shao, F. (2010). Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science 329(5996): 1215-1218

153. Yuan, W., Xie, J., Long, C., Erdjument-Bromage, H., Ding, X., Zheng, Y., Tempst, P., Chen, S., Zhu, B., and Reinberg, D. (2009). Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. J. Biol. Chem. 284(23): 15701-15707

154. Yao, Q., Cui, J., Zhu, Y., Wang, G., Hu, L., Long, C., Cao, R., Liu, X., Huang, N., Chen, S., Liu, L., and Shao, F. (2009). A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle. Proc. Natl. Acad. Sci. U. S. A. 106(10): 3716-3721

155. Yang, K., Shi, H. X., Liu, X. Y., Shan, Y. F., Wei, B., Chen, S., and Wang, C. (2009). TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response. J. Immunol. 182(6): 3782-3792

156. Tang, C. T., Li, S., Long, C., Cha, J., Huang, G., Li, L., Chen, S.^#, and Liu, Y.^# (2009). Setting the pace of the Neurospora circadian clock by multiple independent FRQ phosphorylation events. Proc. Natl. Acad. Sci. U. S. A. 106(26): 10722-10727. (^#共同通訊作者).

157. Paroo, Z., Ye, X., Chen, S., and Liu, Q. (2009). Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling. Cell 139(1): 112-122

158. Monaghan, J., Xu, F., Gao, M., Zhao, Q., Palma, K., Long, C., Chen, S., Zhang, Y., and Li, X. (2009). Two Prp19-like U-box proteins in the MOS4-associated complex play redundant roles in plant innate immunity. PLoS Pathog. 5(7): e1000526

159. Jia, G., Wang, W., Li, H., Mao, Z., Cai, G., Sun, J., Wu, H., Xu, M., Yang, P., Yuan, W., Chen, S., and Zhu, B. (2009). A systematic evaluation of the compatibility of histones containing methyl-lysine analogues with biochemical reactions. Cell Res. 19(10): 1217-1220

160. Gao, M., Wang, X., Wang, D., Xu, F., Ding, X., Zhang, Z., Bi, D., Cheng, Y. T., Chen, S., Li, X., and Zhang, Y. (2009). Regulation of cell death and innate immunity by two receptor-like kinases in Arabidopsis. Cell Host Microbe 6(1): 34-44

161. Ganley, I. G., Lam du, H., Wang, J., Ding, X., Chen, S., and Jiang, X. (2009). ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J. Biol. Chem. 284(18): 12297-12305

162. Sun, Q., Fan, W., Chen, K., Ding, X., Chen, S., and Zhong, Q. (2008). Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. U. S. A. 105(49): 19211-19216

163. Mi, S., Cai, T., Hu, Y., Chen, Y., Hodges, E., Ni, F., Wu, L., Li, S., Zhou, H., Long, C., Chen, S., Hannon, G. J., and Qi, Y. (2008). Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell 133(1): 116-127

164. Zhu, Y., Li, H., Long, C., Hu, L., Xu, H., Liu, L., Chen, S.^#, Wang, D. C.^#, and Shao, F.^# (2007). Structural insights into the enzymatic mechanism of the pathogenic MAPK phosphothreonine lyase. Mol. Cell 28(5): 899-913. ( ^#共同通訊作者).

165. Zhang, J., Shao, F., Li, Y., Cui, H., Chen, L., Li, H., Zou, Y., Long, C., Lan, L., Chai, J., Chen, S., Tang, X., and Zhou, J. M. (2007). A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants. Cell Host Microbe 1(3): 175-185

166. Xing, W., Zou, Y., Liu, Q., Liu, J., Luo, X., Huang, Q., Chen, S., Zhu, L., Bi, R., Hao, Q., Wu, J. W., Zhou, J. M., and Chai, J. (2007). The structural basis for activation of plant immunity by bacterial effector protein AvrPto. Nature 449(7159): 243-247

167. Li, H., Xu, H., Zhou, Y., Zhang, J., Long, C., Li, S., Chen, S., Zhou, J. M., and Shao, F. (2007). The phosphothreonine lyase activity of a bacterial type III effector family. Science 315(5814): 1000-1003

168. Huang, G.*, Chen, S.*, Li, S., Cha, J., Long, C., Li, L., He, Q., and Liu, Y. (2007). Protein kinase A and casein kinases mediate sequential phosphorylation events in the circadian negative feedback loop. Genes Dev. 21(24): 3283-3295. (*共同第一作者).

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